Martin Rosas-Peralta, Silvia Palomo-Piñón, Gabriela Borrayo Sánchez, Gilberto Pérez Rodríguez, José Ramón Paniagua-Sierra, Cardiorenal Signaling Pathways in Heart Failure: Good and Bad News, Journal of Hypertension and Cardiology, Volume 1, Issue 4, 2016, Pages 23-39, ISSN 2329-9487, https://doi.org/10.14302/issn.2329-9487.jhc-15-864. (https://www.oap-bioscience.org/hypertension-and-cardiology/article/cardiorenal-signaling-pathways-in-heart-failure-good-and-bad-news-250) Abstract: This article reviews heart–kidney signaling in heart failure, contrasting adaptive and maladaptive pathways. It discusses neurohormonal activation, fibrosis, and emerging therapeutic targets. Keywords: Heart Failure; Heart-Kidney interactions; Cardiorenal syndrome; diastolic dysfunction; inflammation; fibrosis.